Qunxin She – University of Copenhagen

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Qunxin She

Dr. Qunxin She is the current Director of the Danish Archaea Centre. His laboratory employs Sulfolobus islandicus as the model organism to study archaeal molecular biology. Current research topics include cell cycle checkpoint regulation, CRISPR/Cas-mediated DNA/RNA interferences.

Contact information

Department of Biology
University of Copenhagen
Ole Maaløes Vej 5
DK-2200 Copenhagen N
+45 353 22013
qunxin@bio.ku.dk

Education & Employment

  • 2005-ongoing: Associate Professor at Department of Biology, University of Copenhagen
  • 1996-2004: Assitent/Associate Research Professor at the department of Biological Chemistry, Institute of Molecular Biology, University of Copenhagen
  • 1993-95: Postdoctoral Fellow at Center of Microbiology, Technical University of Denmark
  • 1988-92: PhD Student at Department of Molecular Biology, University of Aarhus
  • 1985-88: Research Assistant at the Oil Crops Institute, CAAS, Wuhan, P.R. China
  • M.Sc. degree in Microbiology with excellent grade from Nanjing Agricultural University in 1985, PR China
  • B.S. degree in Microbiology with excellent grade from Huazhong Agricultural University in 1982, PR China

Research Interests

  • Molecular mechanisms of cell cycle, chromosomal DNA replication and DNA damage repair
  • Molecular mechanism of archaeal CRISPR/Cas, Cmr systems
  • Robust Sulfolobus protein expression systems: biotech application of hyperthermophilic enzymes expressed from Sulfolobus

Selected Publications in 2013-17

  1. Peng, W, Li, H, Hallstrøm, S, Peng, N, Liang, YX & She, Q 2013, Genetic determinants of PAM-dependent DNA targeting and pre-crRNA processing in Sulfolobus islandicus. RNA Biol, 10. 728-748.
  2. L. Deng, R.A. Garrett, S.A. Shah, X. Peng*, Q. She* (2013) Novel interference activity by a type IIIB CRISPR-Cmr module in Sulfolobus. Mol. Microbiol. 87, 1088-1099. Full Text
  3. R.Y. Samson#, Y. Xu#, C. Gadelha, T.A. Stone, J.N. Faqiri, D. Li, N. Qin, F. Pu, Y.X. Liang, Q. She*, and S.D. Bell* (2013) Specificity and function of archaeal replication initiator proteins. Cell Rep. 3, 485-96.
  4. C. Zhang, B. Tian, S. Li, X. Ao, K.D. Dalgaard, S. Gocke, Y. Liang, Q. She (2013) Genetic manipulation in Sulfolobus islandicus and functional analysis of DNA repair genes. Biochem. Soc. Trans. 41, 405-410.
  5. H. Wang, N. Peng, S. A. Shah, L. Huang, Q. She. 2015. Archaeal Extrachromosomal Genetic Elements. Microbiol Mol Biol Rev. 79(1):117-152.
  6.  W. Peng, M. Feng, X. Feng, Y.X. Liang, Q. She. 2015. An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interferenceNucleic Acids Res. 43(1):406-17. 
  7. T. Liu, Y. Li, X. Wang, Q. Ye, H. Li, Y. Liang, Q. She, N. Peng. 2015. Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition. Nucleic Acids Res. 43(2):1044-55.
  8. R.A. Garrett, S.A. Shah, S. Erdmann, G. Liu, M. Mousaei, C. León-Sobrino, W. Peng, S. Gudbergsdottir, L. Deng, G. Vestergaard, X. Peng, Q. She. 2015. CRISPR-Cas Adaptive Immune Systems of the Sulfolobales: Unravelling Their Complexity and Diversity. Life (Basel) 5(1):783-817.
  9. Guannan, Liu; She, Qunxin; Garrett, Roger Antony.2016. Diverse CRISPR-Cas responses and dramatic cellular DNA changes and cell death in pKEF9-conjugated Sulfolobus speciesNucleic Acids Res. Vol. 44, Nr. 9, s. 4233-4242.
  10. She, Qunxin; Han, Wenyuan. 2017. Archaea and CRISPR biology. Microbiology Today, Vol. 44, Nr. 3, 17.08.2017, s. 122-125.
  11. Peng, Nan; Han, Wenyuan; Li, Yingjun; Liang, Yunxiang; She, Qunxin. 2017. Genetic technologies for extremely thermophilic microorganisms of Sulfolobus, the only genetically tractable genus of crenarchaea. Science China Life Sciences, Vol. 60, Nr. 4, 30.04.2017, s. 370-385.
  12. Liu, Tao; Liu, Zhenzhen; Ye, Qing; Pan, Saifu; Wang, Xiaodi; Li, Yingjun; Peng, Wenfang; Liang, Yunxiang; She, Qunxin; Peng, Nan. 2017. Coupling transcriptional activation of CRISPR–Cas system and DNA repair genes by Csa3a in Sulfolobus islandicus.  Nucleic Acids Res. Vol 45, Nr. 15, 2017, s. 8978-8992.
  13. He, Fei; Vestergaard, Gisle; Peng, Wenfang; She, Qunxin; Peng, Xu. 2017. CRISPR-Cas type I-A Cascade complex couples viral infection surveillance to host transcriptional regulation in the dependence of Csa3b. Nucleic Acids Res. Vol. 45, Nr. 4, s. 1902-1913.
  14. Han, Wenyuan; Li, Yingjun; Deng, Ling; Feng, Mingxia; Peng, Wenfang; Hallstrøm, Søren; Zhang, Jing; Peng, Nan; Liang, Yun Xiang; White, Malcolm F.; She, Qunxin. 2017. A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction.  Nucleic Acids Res. Vol. 45, Nr. 4, s. 1983–1993.
  15. Han, Wenyuan; Pan, Saifu; López-Méndez, Blanca; Montoya, Guillermo; She, Qunxin. 2017. Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail. Nucleic Acids Res. Published online Aug. 16, 2017.
  16. Li, Yingjun; Zhang, Yan; Lin, Jinzhong; Pan, Saifu; Han, Wenyuan; Peng, Nan; Liang, Yun Xiang; She, Qunxin. 2017. Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR–Cas system by binding to target RNA and crRNA. Nucleic Acids Res. 2017. Published online Sept. 5, 2017.
  17. Han, Wenyuan; Xu, Yanqun; Feng, Xu; Liang, Yun X.; Huang, Li; Shen, Yulong; She, Qunxin.2017. NQO-induced DNA-less cell formation is associated with chromatin protein degradation and dependent on A0A1-ATPase in Sulfolobus. Front Microbiol. Vol. 8, 1480, 14.08.2017.

For the complete list of publications see papers by Qunxin She