Qunxin She – University of Copenhagen

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Qunxin She

Dr. Qunxin She is the current Director of the Danish Archaea Centre. His laboratory employs Sulfolobus islandicus as the model organism to study archaeal molecular biology. Current research topics include cell cycle checkpoint regulation, CRISPR/Cas-mediated DNA/RNA interferences.

Contact information

Department of Biology
University of Copenhagen
Ole Maaløes Vej 5
DK-2200 Copenhagen N
+45 353 22013

Education & Employment

  • 2005-ongoing: Associate Professor at Department of Biology, University of Copenhagen
  • 1996-2004: Assitent/Associate Research Professor at the department of Biological Chemistry, Institute of Molecular Biology, University of Copenhagen
  • 1993-95: Postdoctoral Fellow at Center of Microbiology, Technical University of Denmark
  • 1988-92: PhD Student at Department of Molecular Biology, University of Aarhus
  • 1985-88: Research Assistant at the Oil Crops Institute, CAAS, Wuhan, P.R. China
  • M.Sc. degree in Microbiology with excellent grade from Nanjing Agricultural University in 1985, PR China
  • B.S. degree in Microbiology with excellent grade from Huazhong Agricultural University in 1982, PR China

Research Interests

  • Molecular mechanisms of cell cycle, chromosomal DNA replication and DNA damage repair
  • Molecular mechanism of archaeal CRISPR/Cas, Cmr systems
  • Robust Sulfolobus protein expression systems: biotech application of hyperthermophilic enzymes expressed from Sulfolobus

Recent Publications (2011-13)

  1. P.-J. Liang, W. Han, Q. Huang, Y. Li, J. Ni, Q. She, Y. Shen. 2013. Knockouts of RecA-Like Proteins RadC1 and RadC2 Have Distinct Responses to DNA Damage Agents in Sulfolobus islandicusJ. Gen. Genom. Published online 7 June 2013.
  2. Peng, W , Li, H, Hallstrøm, S, Peng, N, Liang, YX & She, Q 2013, ' Genetic determinants of PAM-dependent DNA targeting and pre-crRNA processing in Sulfolobus islandicus ' RNA Biol, 10. 728-748.
  3. Fusco, S , She, Q, Bartolucci, S & Contursi, P 2013, ' Tlys, a Newly Identified Sulfolobus Spindle-Shaped Virus 1 Transcript Expressed in the Lysogenic State, Encodes a DNA-Binding Protein Interacting at the Promoters of the Early Genes ' Journal of Virology , vol 87, nr. 10, s. 5926-36.
  4. Ren, Y , She, Q & Huang, L 2013, ' Transcriptomic analysis of the SSV2 infection ofSulfolobus solfataricus with and without the integrative plasmid pSSVi ' Virology, 441, 126-134.
  5. Okutan, E , Deng, L , Mirlashari, S , Uldahl, K , Halim, M , Liu, C , Garrett, RA , She, Q & Peng, X 2013, ' Novel insights into gene regulation of the rudivirus SIRV2 infectingSulfolobus cells RNA Biol, 10, 875-885.
  6. Jaubert, C, Danioux, C, Oberto, J, Cortez, D, Bize, A, Krupovic, M , She, Q , Forterre, P, Prangishvili, D & Sezonov, G 2013, ' Genomics and genetics of Sulfolobus islandicus LAL14/1, a model hyperthermophilic archaeon ' Open Biology , vol 3, nr. 4, s. 130010.
  7. Shi, Y, Pan, Y, Li, B, He, W, She, Q & Chen, L. 2013, ' Molecular cloning of a novel bioH gene from an environmental metagenome encoding a carboxylesterase with exceptional tolerance to organic solvents ' BMC Biotechnol, 13, (1), Feb 15;13:13.
  8. L. Deng, R.A. Garrett, S.A. Shah, X. Peng*, Q. She* (2013) Novel interference activity by a type IIIB CRISPR-Cmr module in Sulfolobus. Mol. Microbiol. 87, 1088-1099. Full Text
  9. R.Y. Samson#, Y. Xu#, C. Gadelha, T.A. Stone, J.N. Faqiri, D. Li, N. Qin, F. Pu, Y.X. Liang, Q. She*, and S.D. Bell* (2013) Specificity and function of archaeal replication initiator proteins. Cell Rep. 3, 485-96. Full text
  10. C. Zhang, B. Tian, S. Li, X. Ao, K.D. Dalgaard, S. Gocke, Y. Liang, Q. She (2013) Genetic manipulation in Sulfolobus islandicus and functional analysis of DNA repair genes. Biochem. Soc. Trans. 41, 405-410
  11.  Hu Y, Peng N, Han W, Mei Y, Chen Z, Feng X,  Liang YX*, Q. She* (2012) An archaeal protein evolutionarily conserved in prokaryotes is a zinc-dependent metalloprotease. Biosci. Rep. 32, 609-618. Full text
  12.  Peng N, Deng L, Mei Y, Jiang D, Hu Y, Awayez M, Liang YX*, Q. She* (2012) A Synthetic Arabinose-Inducible Promoter Confers High Levels of Recombinant Protein Expression in Hyperthermophilic Archaeon Sulfolobus islandicus. Appl. Environ. Microbiol. 78, 5630-5637.
  13.  Peng X, Garrett RA, She Q (2012) Archaeal viruses--novel, diverse and enigmatic. Sci China Life Sci 55, 422-433. Full text
  14. Deng L, Kerchappa CS, Peng X, She Q*, Garrett RA* (2012) Modulation of CRISPR locus transcription by the repeat-binding protein Cbp1 in Sulfolobus. Nucleic Acids Res 40, 2470-2480. Full Content
  15. Zheng T, Huang Q, Zhang C, Ni J, She Q*, Shen Y* (2012) Development of simvastatin selection marker for hyperthermophilic acidophile Sulfolobus islandicus. Appl Environ Microbiol 78, 568-574. Full text
  16.  Hong Y, Chu M, Li Y, Ni J, Sheng D, Hou G, She Q*, Shen Y* (2012) Dissection of the functional domains of an archaeal Holliday junction helicase. DNA Repair 11, 102-111. Abstract
  17. Mei Y, Peng N, Zhao S, Hu Y, Wang H, Liang Y*, She Q* (2012) Exceptional thermal stability and organic solvent tolerance of an esterase expressed from a thermophilic host. Appl Microbiol Biotechnol  93, 1965-1974. Abstract
  18.  Li X, Guo L, Deng L, Feng D, Ren Y, Chu Y, She Q*, Huang L* (2011) Deletion of the topoisomerase III gene in the hyperthermophilic archaeon Sulfolobus islandicus results in slow growth and defects in cell cycle control. J Genet Genom 38, 253-9. Abstract
  19.  You XY, Liu C, Wang SY, Jiang CY, Shah SA, Prangishvili D, She Q, Liu SJ, Garrett RA. (2011) Genomic analysis of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles. Extremophiles 15, 487-97. Full Content
  20.  Snyder JC, Brumfield SK, Peng N, She Q, Young MJ (2011) Sulfolobus Turreted Icosahedral Virus c92 protein responsible for formation of pyramid-like cellular lysis structures. J Virol 85, 6287-92.  Abstract
  21.  Lintner NG, Kerou M, Brumfield SK, Graham S, Liu H, Naismith JH, Sdano M, Peng N, She Q, Copie V, Young MJ, White MF, Lawrence CM (2011) Structural and functional characterization of an archaeal CASCADE complex for CRISPR-mediated viral defense. J Biol Chem 286, 21643-56.  Abstract
  22.  Guo L, Brugger K, Liu C, Shah SA, Zheng H, Zhu Y, Wang S, Lillestol RK, Chen L, Frank J, Prangishvili D, Paulin L, She Q, Huang L, Garrett RA (2011) Genome Analyses of Icelandic Strains of Sulfolobus islandicus: Model Organisms for Genetic and Virus-Host Interaction Studies. J Bacteriol 193, 1672-80. Abstract
  23. Peng, N., Ao, X., Liang, Y. X., She Q (2011) Archaeal promoter architecture and mechanism of gene activation. Biochem Soc Trans 39, 99-103. Abstract
  24.  Garrett R A, Shah S A, Vestergaard G, Deng L, Gudbergsdottir S, Kenchappa, CS, Erdmann S, She Q (2011) CRISPR-based immune systems of the Sulfolobales: complexity and diversity. Biochem Soc Trans 39, 51-57. Abstract
  25.  Gudbergsdottir S, Deng L, Chen Z, Jensen JV, Jensen LR, She Q*, Garrett RA* (2011) Dynamic properties of the Sulfolobus CRISPR/Cas and CRISPR/Cmr systems when challenged with vector-borne viral and plasmid genes and protospacers. Mol Microbiol 79, 35-49. Full Content
  26.  Contursi P, D'Ambrosio K, Pirone L, Pedone E, Aucelli T, She Q, De Simone G, Bartolucci S (2011) c68 from the Sulfolobus islandicus plasmid/virus pSSVx is a novel member of the AbrB-like transcription factor family. Biochem J 435, 157-66. Abstract
  27.  Zhu X, Liu W, Lametsch R, Aarestrup F, Shi C, She Q*, Shi X*, Knochel S (2011) Phenotypic, Proteomic, and Genomic Characterization of a Putative ABC-transporter Permease Involved in Listeria monocytogenes Biofilm Formation. Foodborne Pathog Dis 8, 495-501. Abstract

Selected Early Publications (2001-2010)